St Louis International Airport is located 13 miles from downtown St. Louis. Average travel time is 20-30 minutes.
| From | Directions |
| Downtown St. Louis | I-70 West to Exit 238A |
| St. Charles/the west | I-70 East to Exit 235C |
| Clayton/the south | I-170 North to Exit 7C |
| The north | I-170 South |
| To | Directions |
| Downtown St. Louis | I-70 East |
| St. Charles/the west | I-70 West |
| Clayton/the south | I-170 South |
| The north | I-170 North |