Midway Airport is located 10 miles from downtown Chicago.
| Starting Location | Expressway From Midway | Expressway To Midway |
| Downtown Chicago | I-55 North to Chicago Loop | I-55 South |
| North Suburbs | I-55 South to I-294 North to I-290 North | I-290 South to I-294 South to I-55 North |
| South Suburbs | I-294 South | I-294 North |
| West Suburbs | I-55 South to I-294 North to I-88 West | 1-88 East to I-294 South to I-55 North |
| Rockford | I-290 West to IL-53 North to I-90 West | I-90 East to Exit #53 South to IL 50 which is Exit #286 (make a left) towards Cicero |
| Wisconsin | I-55 North to I-90 West to I-94 West to I-294 North | I-294 South to I-94 East to 1-90 East to 1-55 South |
| Indiana | I-55 North to I-90/94 East to I-90 East Chicago Skyway | I-90 East Chicago Skyway to I-90/94 West to I-55 South |